Synthetic autocatalysts show organocatalysis of other reactions.

نویسندگان

  • Seiji Kamioka
  • Dariush Ajami
  • Julius Rebek
چکیده

A molecule capable of both autocatalysis and organocatalysis was synthesized. The autocatalytic activity results from the self-complementary recognition sites provided by hydrogen bonding between heterocyclic subunits and the organocatalysis resides in an embedded thiourea function. The behavior of the molecule suggests both replication and metabolism can be engineered into synthetic compounds.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Photo-Organocatalysis, Photo-Redox, and Electro- Organocatalysis Processes

The research involving photo-organocatalysis, photoredox, and electro-organocataly‐ sis processes is revised in this chapter. Modern synthetic processes enable the formation of large arrays of organic molecules with precise control over their three-dimensional structure, which is important in a variety of fields ranging from pharmaceutical to materials science. Photochemical reactions may have ...

متن کامل

New Concepts for Catalysis

Organocatalysis, the catalysis with low-molecular weight catalysts where a metal is not part of the catalytic principle, can be as efficient and selective as metalor biocatalysis. Important discoveries in this area include novel Lewis base-catalyzed enantioselective processes and, more recently, simple Brønsted acid organocatalysts that rival the efficiency of traditional metal-based asymmetric...

متن کامل

7 . Strategies for the synthesis of enantiopure compounds focused on organocatalysis

The preparation of enantiomerically pure compounds (EPC) is a continuous social demand due to the clinical advantages that enantiopure drugs offer over the racemic forms. Here, the best well-established synthetic strategies to access to single-enantiomer compounds are briefly described and compared. In particular, the enantioselective catalysis is introduced paying special attention to the orga...

متن کامل

Sequential enantiodivergent organocatalysis: reversibility in enantioswitching controlled by a conformationally flexible guanidine/bisthiourea organocatalyst.

Here we describe our studies on solvent-dependent enantiodivergent Mannich-type reactions utilizing conformationally flexible guanidine/bisthiourea organocatalyst (S,S)-1. Our mechanistic investigations revealed that the stereo-determining steps in both the (R)- and (S)-selective Mannich-type reactions are governed by the cooperative effect of guanidine and thiourea in the inherently monomeric ...

متن کامل

The potential of pnicogen bonding for catalysis - a computational study.

Pnicogen bonding is a noncovalent interaction between the electrophilic region of a phosphorus atom and a Lewis base. Although this interaction can be comparable in strength to other noncovalent interactions, no systematic application in organic synthesis or catalysis is known so far. To identify the potential of this interaction for organocatalysis, we have now analysed different pnicogen-bond...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Chemical communications

دوره 47  شماره 

صفحات  -

تاریخ انتشار 2009